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Innovations in Cannabis Research – Interviews With Industry Professionals

In this most recent podcast episode, two cannabis research experts – Professor Nassim Garti and Haleli Sharir PhD – discuss some of their companies’ latest developments in the medical cannabis field. This interview is brought to you by our friends Heli Dangur and Narkis Tessler from CannaCAST IL, Israel’s leading medical cannabis podcast. They formed […]

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In this most recent podcast episode, two cannabis research experts – Professor Nassim Garti and Haleli Sharir PhD – discuss some of their companies’ latest developments in the medical cannabis field.

This interview is brought to you by our friends Heli Dangur and Narkis Tessler from CannaCAST IL, Israel’s leading medical cannabis podcast. They formed this show with the primary goal of educating and empowering the medical cannabis community by offering international exposure to Israel’s groundbreaking technology, R&D, and innovation.

Their first guest of this episode was Professor Nissim Garti from the Casali Institute of Applied Chemistry at the Hebrew University of Jerusalem. Prof. Garti has written 10 peer reviewed publications, 14 edited books, 85 chapters in books, and over 90 patents. He also runs a drug delivery company called Lyotropic Delivery Systems (LDS).


Right now, Prof. Garti and his team are working on developing Novel Delivery Systems for cannabis based on nano technology. They are preparing to begin clinical trials to prove the efficiency of nano droplets as opposed to CBD oil. 

“Most of the extractions today are done either in alcohols or liquid CO2. We are extracting with our nano domains. There is no real solvent used, it is actually nano domains. So we’re taking the flowers, and after they’re dried and heated, we’re extracting from them only the active ingredients.. no oil. The extraction is unique and the formulation is unique.”

According to Gardi, with this method it takes only 15 minutes for the CBD to permeate the blood stream, compared to 2 hours or more when using oil. Furthermore, higher amounts of CBD are delivered into the bloodstream via this method. Also, nano technology would make the CBD more stable. With proper care and storage, it is expected to have a much longer shelf life.

This would lead to reduced doses, cause less interference from other cannabinoids and compounds, and result in money saved due to increased bioavailability. It’s a win-win (win) situation. 


Next up is Haleli Sharir, PhD and VP of R&D at Cannabics Pharmaceuticals. Sharir discovered a new cannabinoid receptor GPR55 and has published 9 peer reviewed essays on the topic. Her company focuses on personalized cannabinoid based therapies for cancer patients.

They utilize a state of the art research facility, strain library, screening tools used to match cannabis strains to specific tumors for individual patients. They are also the only company to use a combination of other “botanical extracts” and they are licensed by the Israeli Ministry of Health, which gives them access to advanced research technology.

“We did participate in a clinical trial, which elucidated the role of the SR capsule into the palliative effect of different formulations for the side effects such as nausea. The research facility is currently doing more pre-clinical trials”

As you can see, researcher in Israel are really making strides on some of the biggest topics in medical cannabis today: bioavailability and personalized treatment options.

Check back with us for more exciting and informative interviews. 

The post Innovations in Cannabis Research – Interviews With Industry Professionals appeared first on CBD Testers.

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DEA’s Latest Policy Change Another Burden on Cannabis Research

CANNABIS CULTURE –  Dr. John Streicher of the University of Arizona says the DEA’s new regulations offer no help to researchers — and he’s not the only one. “From my point of view it makes no difference at all,” Streicher says under the new rules he w…

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CANNABIS CULTURE –  Dr. John Streicher of the University of Arizona says the DEA’s new regulations offer no help to researchers — and he’s not the only one. “From my point of view it makes no difference at all,” Streicher says under the new rules he will still need to file for a Schedule I license with the DEA, as he did under the old regulations.  Streicher’s research focuses on pain management, often with opioids…

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Cannabis May Enhance Cognition and Memory

In 2017, researcher Andreas Zimmer of the University of Bonn in Germany published his study titled Cannabis reverses aging process in the brain. The results of the study were published in Natural Medicine, a peer-reviewed medical journal. Zimmer and his team found that when older mice were given a low-dose cannabis treatment their memory improved…

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In 2017, researcher Andreas Zimmer of the University of Bonn in Germany published his study titled Cannabis reverses aging process in the brain. The results of the study were published in Natural Medicine, a peer-reviewed medical journal.

Zimmer and his team found that when older mice were given a low-dose cannabis treatment their memory improved to the average age of a two-month old mouse. Generally, mice memories begin to decline at the age of twelve months, according to the study.

This study gives hope to those who suffer from Alzheimer’s Disease, dementia and other brain-affected conditions. Cannabis is accessible in many forms which is ideal for older patients. According to the National Institute on Aging, Alzheimer’s Disease affects 5.5 million Americans. The disease is the sixth leading cause of death in the United States and Alzheimer’s Disease frequently leads to dementia.

Zimmer’s study took years to complete as there were multiple steps in the research process. It was determined that older mice lacked the CB1 receptors. Cannabinoids occur naturally as proteins which are essential in THC “docking” and “triggering a signal.” Zimmer assessed that during the aging process cannabinoids no longer formed in the brain.

THC imitates the effect of cannabinoids produced naturally in the body.

Zimmer reports, “The molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability.”

The research team is currently adapting the study to test on human participants.

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DEA Finally Agrees to Expand Marijuana Research Amid Pressure from Lawsuit

  A standoff between marijuana researchers and federal drug enforcement may finally have turned in the scientists’ favour. As we reported earlier, marijuana experts were frustrated over the poor quality of cannabis grown at the government’s only legal marijuana facility … Readmore

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A standoff between marijuana researchers and federal drug enforcement may finally have turned in the scientists’ favour.

As we reported earlier, marijuana experts were frustrated over the poor quality of cannabis grown at the government’s only legal marijuana facility at the University of Mississippi. They claimed it was essentially unusable for their research and demanded that the Drug Enforcement Administration respond to a plethora of applications to grow better cannabis.

The applications were submitted as far back as 2016. Despite a 90-day deadline for review, the DEA ignored this cut-off and simply sat on the applications for three years. This likely would have been longer, but the DEA had not anticipated a legal threat to force some action.

Their silence – despite claiming to be interested in more studies – led the Scottsdale Research Institute (SRI) to sue the DEA, demanding that they finally review the multiple applications sitting in limbo.

Now, CBS News reveals – just a hair before the deadline – the DEA issued a response that, assuming they follow through, opens the door to a plethora of excellent studies.

 

“Dozens of Applications”

 

The DEA dragged its feet for as long as possible, but the deadline for a response eventually came.

 “Two days before a deadline to respond to a lawsuit brought by researchers, the Drug Enforcement Administration filed a notice in the Federal Register acknowledging dozens of applications from potential growers. DEA Acting Administrator Uttam Dhillon said the agency is ‘making progress in the program to register additional marijuana growers for federally authorized research, and will work with other relevant federal agencies to expedite the necessary next steps.’”

This is a rather sudden change from the DEA’s previous approach, which involved flat-out ignoring the pleas of researchers and – in the lawsuit’s case – the veterans these scientists were hoping to help.

 

A Small Step in the Right Direction

 

Given the DEA’s stonewalling, forcing their hand is a notable achievement. However, there is still one way the DEA could cause further delays.

CBS News explains that the DEA wishes to “propose new regulations for growers” before actually issuing permits. This effectively keeps the ball in their court, giving them the ability to hold out until scientists once again get fed up.

Nonetheless, Attorney General William Barr praised the outcome, saying he is:

 

“…pleased that DEA is moving forward with its review of applications for those who seek to grow marijuana legally to support research.”

 

SRI’s main investigator, Dr. Sue Sisley, acknowledged the importance of applying research to strains that are actually available in the open and illicit market. We can infer she means marijuana high in THC. The current rules only allow researchers to grow low-THC plants more genetically similar to hemp.

Sisley refers to the DEA’s concession as a “historic victory,” further saying in an e-mail:

 

“Now we just need to keep the DEA’s feet to the fire and make sure they follow their own timelines they laid out in today’s public notice. It’s going to take a long time to get access to newly cultivated cannabis material for research, but at least that door is now kicked open.”

 

Hopefully, Sisley’s optimism is founded, but based on its history, the DEA will need to be under constant pressure to follow through with its promise.

 

WeedAdvisors Support for Medical Cannabis Research

 

We find it very unfortunate when hard-headed bureaucracy gets in the way of legitimate research. Sadly, the stigma around cannabis is still alive and well. When that stigma permeates the minds of those in power, policies reflect that and create serious roadblocks.

RSI’s move to make this a legal matter was a very bold move, but ultimately it produced results. We will continue to cover the latest discoveries in WeedAdvisor’s ongoing goal to not only support cannabis organizations with our business solutions, but also educate the general public.

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